FAM33A Antikörper (AA 1-121)

Produktnummer ABIN7170591

Der Kaninchen Polyklonal Anti-FAM33A-Antikörper wurde für ELISA und IHC validiert. Er ist geeignet, FAM33A in Proben von Human zu detektieren.

Kurzübersicht für FAM33A Antikörper (AA 1-121) (ABIN7170591)

Target: FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM33A Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-FAM33A Antikörper

Bindungsspezifität: AA 1-121

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Spindle and kinetochore-associated protein 2 protein (1-121AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FAM33A

Target: FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))

Andere Bezeichnung: SKA2

Hintergrund:

Background: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).

Aliases: FAM33A antibody, Family with sequence similarity 33, member A antibody, FLJ12758 antibody, MGC110975 antibody, Protein FAM33A antibody, SKA 2 antibody, SKA2 antibody, SKA2_HUMAN antibody, Spindle and kinetochore associated complex subunit 2 antibody, Spindle and kinetochore associated protein 2 antibody, Spindle and kinetochore-associated protein 2 antibody, Spindle and KT (kinetochore) associated 2 antibody, Spindle and KT associated 2 antibody

UniProt: Q8WVK7

Pathways: M Phase