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FAM33A Antikörper (N-Term)

FAM33A Reaktivität: Human, Maus ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991191
  • Target Alle FAM33A Antikörper anzeigen
    FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))
    Bindungsspezifität
    • 9
    • 8
    • 6
    • 4
    • 1
    • 1
    N-Term
    Reaktivität
    Human, Maus
    Wirt
    • 22
    Kaninchen
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 9
    • 3
    • 3
    • 3
    • 2
    • 2
    Dieser FAM33A Antikörper ist unkonjugiert
    Applikation
    • 17
    • 17
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Aufreinigung
    SKA2 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    SKA2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human SKA2. The immunogen is located within the first 50 amino acids of SKA2.
    Isotyp
    IgG
    Top Product
    Discover our top product FAM33A Primärantikörper
  • Applikationshinweise
    SKA2 antibody can be used for detection of SKA2 by Western blot at 0.5 - 1 μ,g/mL.

    Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    SKA2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    SKA2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))
    Andere Bezeichnung
    SKA2 (FAM33A Produkte)
    Synonyme
    FAM33A antikoerper, 1110001A07Rik antikoerper, C78640 antikoerper, Fam33a antikoerper, RGD1307084 antikoerper, fam33a antikoerper, spindle and kinetochore associated complex subunit 2 antikoerper, Spindle and kinetochore-associated protein 2 antikoerper, SKA2 antikoerper, Ska2 antikoerper, ska2 antikoerper
    Hintergrund
    SKA2 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.
    Gen-ID
    348235
    NCBI Accession
    NP_872426
    UniProt
    Q8WVK7
    Pathways
    M Phase
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