PINK1 Antikörper (AA 162-272)

Produktnummer ABIN7169153

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PINK1 in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PINK1 Antikörper (AA 162-272) (ABIN7169153)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINK1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-PINK1 Antikörper

Bindungsspezifität: AA 162-272

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase PINK1, mitochondrial protein (162-272AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Andere Bezeichnung: PINK1

Hintergrund:

Background: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at \\\'Ser-65\\\' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291).

Aliases: BRPK antibody, FLJ27236 antibody, mitochondrial antibody, PARK 6 antibody, PARK6 antibody, Phosphatase and Tensin Homolog antibody, PINK 1 antibody, PINK1 antibody, PINK1_HUMAN antibody, Protein kinase BRPK antibody, PTEN induced putative kinase 1 antibody, PTEN induced putative kinase protein 1 antibody, PTEN-induced putative kinase protein 1 antibody, Serine/threonine kinase PINK1 mitochondrial antibody, Serine/threonine protein kinase PINK1 mitochondrial antibody, Serine/threonine-protein kinase PINK1 antibody

UniProt: Q9BXM7

Pathways: Autophagie