RAPGEF2 Antikörper (AA 1393-1498)

Produktnummer ABIN7167104

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RAPGEF2 in ELISA und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für RAPGEF2 Antikörper (AA 1393-1498) (ABIN7167104)

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAPGEF2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-RAPGEF2 Antikörper

Bindungsspezifität: AA 1393-1498

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Rap guanine nucleotide exchange factor 2 protein (1393-1498AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RAPGEF2

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Andere Bezeichnung: RAPGEF2

Hintergrund:

Background: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.

Aliases: CNrasGEF antibody, Cyclic nucleotide ras GEF antibody, KIAA0313 antibody, Neural RAP guanine nucleotide exchange protein antibody, nRap GEP antibody, NRAPGEP antibody, PDZ domain containing guanine nucleotide exchange factor 1 antibody, PDZ domain-containing guanine nucleotide exchange factor 1 antibody, PDZ GEF1 antibody, PDZ-GEF1 antibody, PDZGEF1 antibody, RA GEF antibody, RA-GEF-1 antibody, Rap guanine nucleotide exchange factor 2 antibody, Rapgef2 antibody, Ras/Rap1-associating GEF-1 antibody, RPGF2_HUMAN antibody

UniProt: Q9Y4G8

Pathways: Neurotrophin Signalübertragung