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RAPGEF2 Antikörper (AA 1393-1498) (FITC)

RAPGEF2 Reaktivität: Human Wirt: Kaninchen Polyclonal FITC
Produktnummer ABIN7167106
  • Target Alle RAPGEF2 Antikörper anzeigen
    RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))
    Bindungsspezifität
    • 15
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1393-1498
    Reaktivität
    • 29
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 27
    • 2
    Kaninchen
    Klonalität
    • 28
    • 1
    Polyklonal
    Konjugat
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RAPGEF2 Antikörper ist konjugiert mit FITC
    Applikation
    Bitte anfragen
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Rap guanine nucleotide exchange factor 2 protein (1393-1498AA)
    Isotyp
    IgG
    Top Product
    Discover our top product RAPGEF2 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))
    Andere Bezeichnung
    RAPGEF2 (RAPGEF2 Produkte)
    Synonyme
    MGC83978 antikoerper, RAPGEF2 antikoerper, fa11h07 antikoerper, wu:fa11h07 antikoerper, CNrasGEF antikoerper, NRAPGEP antikoerper, PDZ-GEF1 antikoerper, PDZGEF1 antikoerper, RA-GEF antikoerper, Rap-GEP antikoerper, nRap GEP antikoerper, 5830453M24Rik antikoerper, CNRasGEF antikoerper, Pdzgef1 antikoerper, RA-GEF-1 antikoerper, mKIAA0313 antikoerper, nRapGEP antikoerper, Rap guanine nucleotide exchange factor 2 antikoerper, Rap guanine nucleotide exchange factor 2 L homeolog antikoerper, Rap guanine nucleotide exchange factor (GEF) 2 antikoerper, RAPGEF2 antikoerper, rapgef2.L antikoerper, rapgef2 antikoerper, Rapgef2 antikoerper
    Hintergrund

    Background: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.

    Aliases: CNrasGEF antibody, Cyclic nucleotide ras GEF antibody, KIAA0313 antibody, Neural RAP guanine nucleotide exchange protein antibody, nRap GEP antibody, NRAPGEP antibody, PDZ domain containing guanine nucleotide exchange factor 1 antibody, PDZ domain-containing guanine nucleotide exchange factor 1 antibody, PDZ GEF1 antibody, PDZ-GEF1 antibody, PDZGEF1 antibody, RA GEF antibody, RA-GEF-1 antibody, Rap guanine nucleotide exchange factor 2 antibody, Rapgef2 antibody, Ras/Rap1-associating GEF-1 antibody, RPGF2_HUMAN antibody

    UniProt
    Q9Y4G8
    Pathways
    Neurotrophin Signalübertragung
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