POT1 Antikörper (AA 250-432) (FITC)

Produktnummer ABIN7165000

Dieses Anti-POT1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von POT1 in . Geeignet für Human.

Kurzübersicht für POT1 Antikörper (AA 250-432) (FITC) (ABIN7165000)

Target: POT1 (Protection of Telomeres 1 (POT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POT1 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-POT1 Antikörper (FITC)

Bindungsspezifität: AA 250-432

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Protection of telomeres protein 1 protein (250-432AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu POT1

Target: POT1 (Protection of Telomeres 1 (POT1))

Andere Bezeichnung: POT1

Hintergrund:

Background: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5\'-TTAGGG-3\' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5\'-TAGGGTTAG-3\' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3\'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.

Aliases: DKFZP586D211 antibody, hPot 1 antibody, hPot1 antibody, POT 1 antibody, POT1 antibody, POT1 like telomere end-binding protein antibody, POT1 protection of telomeres 1 homolog antibody, POT1-like telomere end-binding protein antibody, POTE1_HUMAN antibody, Protection of telomeres 1 antibody, Protection of telomeres 1 homolog (S. pombe) antibody, Protection of telomeres protein 1 antibody

UniProt: Q9NUX5

Pathways: Zellzyklus, Telomere Maintenance