Presenilin 1 Antikörper (AA 4-218) (Biotin)
Kurzübersicht für Presenilin 1 Antikörper (AA 4-218) (Biotin) (ABIN7164265)
Target
Alle Presenilin 1 (PSEN1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 4-218
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Verwendungszweck
- PSEN1 Antibody, Biotin conjugated
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Aufreinigung
- Protein G purified
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Reinheit
- >95 %
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Immunogen
- Recombinant Human Presenilin-1 protein (4-218AA)
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Isotyp
- IgG
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anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 330-359), (C-Term) antibodyPSEN1 Reaktivität: Human, Maus WB, IHC (p), FACS, IF Wirt: Kaninchen Polyclonal RB2257 unconjugated
anti-Presenilin 1 (PSEN1) (pSer310) antibodyKD Validated PSEN1 Reaktivität: Human WB, FACS Wirt: Kaninchen Monoclonal 24GB4510 unconjugated Recombinant Antibody
anti-Presenilin 1 (PSEN1) (AA 4-218) antibodyPSEN1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (Middle Region) antibodyPSEN1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd, Kaninchen WB, IHC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 1-160) antibodyPSEN1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 300-349) antibodyPSEN1 Reaktivität: Human, Maus, Affe, Rind (Kuh), Schwein, Meerschweinchen, Pferd WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 107-156) antibodyPSEN1 Reaktivität: Human, Maus, Ratte, Affe, Schwein, Meerschweinchen, Hund, Fledermaus, Hamster WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (N-Term) antibodyPSEN1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd, Kaninchen, Zebrafisch (Danio rerio) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (Ser45), (Thr41) antibodyPSEN1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Presenilin 1 (PSEN1)
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Andere Bezeichnung
- PSEN1
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Hintergrund
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Background: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Aliases: AD3 antibody, Ad3h antibody, FAD antibody, Homo Sapiens Clone CC44 Senilin 1 antibody, Presenilin-1 CTF12 antibody, Protein S182 antibody, PS 1 antibody, PS-1 antibody, PS1-CTF12 antibody, PSEN1 antibody, PSN1_HUMAN antibody, PSNL1 antibody, S182 antibody
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UniProt
- P49768
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Pathways
- Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
Target
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