PARN Antikörper (AA 1-639) (Biotin)

Produktnummer ABIN7163762

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PARN in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PARN Antikörper (AA 1-639) (Biotin) (ABIN7163762)

Target: PARN (Poly A Specific Ribonuclease (PARN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARN Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-PARN Antikörper (Biotin)

Bindungsspezifität: AA 1-639

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Poly(A)-specific ribonuclease PARN protein (1-639AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PARN

Target: PARN (Poly A Specific Ribonuclease (PARN))

Andere Bezeichnung: PARN

Hintergrund:

Background: 3\'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3\'-end poly(A) tail and the 5\'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3\'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

Aliases: DAN antibody, Deadenylating nuclease antibody, Deadenylation nuclease antibody, PARN antibody, PARN_HUMAN antibody, Poly A specific ribonuclease antibody, Poly(A) specific ribonuclease antibody, Poly(A)-specific ribonuclease PARN antibody, Polyadenylate specific ribonuclease antibody, Polyadenylate-specific ribonuclease antibody

UniProt: O95453