Poliovirus Receptor Antikörper (AA 220-345)

Produktnummer ABIN7163737

Dieses Anti-Poliovirus Receptor-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Poliovirus Receptor in WB, IHC und ELISA. Geeignet für Human.

Kurzübersicht für Poliovirus Receptor Antikörper (AA 220-345) (ABIN7163737)

Target: Poliovirus Receptor (PVR)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Poliovirus Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Poliovirus Receptor Antikörper

Bindungsspezifität: AA 220-345

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Poliovirus receptor protein (220-345AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Poliovirus Receptor

Target: Poliovirus Receptor (PVR)

Andere Bezeichnung: PVR

Hintergrund:

Background: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.2 Publications

Aliases: CD155 antibody, CD155 antigen antibody, FLJ25946 antibody, HVED antibody, mE4 antibody, NECL 5 antibody, Necl-5 antibody, Necl5 antibody, Nectin like 5 antibody, Nectin like protein 5 antibody, Nectin-like protein 5 antibody, Ortholog of mouse Tage4 antibody, Poliovirus receptor antibody, PVR antibody, PVR_HUMAN antibody, PVS antibody, Taa1 antibody, Tage 4 antibody, TAGE4 antibody

UniProt: P15151

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interaktom