PODXL Antikörper (AA 32-458) (Biotin)

Produktnummer ABIN7163725

Dieses Anti-PODXL-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PODXL in ELISA. Geeignet für Human.

Kurzübersicht für PODXL Antikörper (AA 32-458) (Biotin) (ABIN7163725)

Target: PODXL (Podocalyxin-Like (PODXL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PODXL Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-PODXL Antikörper (Biotin)

Bindungsspezifität: AA 32-458

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Podocalyxin protein (32-458AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PODXL

Target: PODXL (Podocalyxin-Like (PODXL))

Andere Bezeichnung: PODXL

Hintergrund:

Background: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Aliases: GCTM-2 antigen antibody, Gp2 antibody, Gp200 antibody, MGC138240 antibody, PC antibody, PCLP antibody, PCLP-1 antibody, PCLP1 antibody, Pcx antibody, Podocalyxin antibody, Podocalyxin like antibody, Podocalyxin like protein antibody, Podocalyxin-like protein 1 antibody, Podxl antibody, PODXL_HUMAN antibody

UniProt: O00592

Pathways: Tube Formation