Tuberin Antikörper (pSer664) (HRP)

Produktnummer ABIN712145

Der Kaninchen Polyklonal Anti-Tuberin-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, Tuberin in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Tuberin Antikörper (pSer664) (HRP) (ABIN712145)

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tuberin Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Tuberin Antikörper (HRP)

Bindungsspezifität: pSer664

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Tuberin around the phosphorylation site of Ser664

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:100-1000, IHC-P: 1:100-500
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % Gentamicin.

Konservierungsmittel: Gentamicin sulfate

Vorsichtsmaßnahmen: This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at 4 °C

Haltbarkeit: 12 months

Details zu Tuberin

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Andere Bezeichnung: Tsc2

Hintergrund:

Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.

Synonyms: TSC2phospho S664,FLJ43106, LAM, TSC2, TSC2_HUMAN, TSC4, Tuberin, Tuberous sclerosis 2 protein.

Gen-ID: 7249

Pathways: RTK Signalweg, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus