WWP2 Antikörper (AA 145-367)

Produktnummer ABIN7161126

Der Kaninchen Polyklonal Anti-WWP2-Antikörper wurde für IHC und ELISA validiert. Er ist geeignet, WWP2 in Proben von Human zu detektieren.

Kurzübersicht für WWP2 Antikörper (AA 145-367) (ABIN7161126)

Target: WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWP2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-WWP2 Antikörper

Bindungsspezifität: AA 145-367

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human NEDD4-like E3 ubiquitin-protein ligase WWP2 protein (145-367AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu WWP2

Target: WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))

Andere Bezeichnung: WWP2

Hintergrund:

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by \\\'Lys-63\\\'-linked conjugation and promotes it to proteasomal degradation, in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation, in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2, the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Aliases: WWP2NEDD4-like E3 ubiquitin-protein ligase WWP2 antibody, EC 2.3.2.26 antibody, Atrophin-1-interacting protein 2 antibody, AIP2 antibody, HECT-type E3 ubiquitin transferase WWP2 antibody, WW domain-containing protein 2 antibody

UniProt: O00308

Pathways: Negative Regulation of Transporter Activity