WWP2 Antikörper (AA 145-367)
Kurzübersicht für WWP2 Antikörper (AA 145-367) (ABIN7161126)
Target
Alle WWP2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 145-367
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Kreuzreaktivität
- Human
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Aufreinigung
- >95%, Protein G purified
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Immunogen
- Recombinant Human NEDD4-like E3 ubiquitin-protein ligase WWP2 protein (145-367AA)
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Isotyp
- IgG
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Applikationshinweise
- Recommended dilution: IHC:1:20-1:200,
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))
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Andere Bezeichnung
- WWP2
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Hintergrund
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Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by \\\'Lys-63\\\'-linked conjugation and promotes it to proteasomal degradation, in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation, in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2, the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
Aliases: WWP2NEDD4-like E3 ubiquitin-protein ligase WWP2 antibody, EC 2.3.2.26 antibody, Atrophin-1-interacting protein 2 antibody, AIP2 antibody, HECT-type E3 ubiquitin transferase WWP2 antibody, WW domain-containing protein 2 antibody
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UniProt
- O00308
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Pathways
- Negative Regulation of Transporter Activity
Target
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