MAPK13 Antikörper (AA 1-365) (Biotin)

Produktnummer ABIN7159991

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAPK13 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MAPK13 Antikörper (AA 1-365) (Biotin) (ABIN7159991)

Target: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPK13 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-MAPK13 Antikörper (Biotin)

Bindungsspezifität: AA 1-365

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Mitogen-activated protein kinase 13 protein (1-365AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAPK13

Target: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Andere Bezeichnung: MAPK13

Hintergrund:

Background: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

Aliases: MAP kinase 13 antibody, MAP kinase p38 delta antibody, MAPK 13 antibody, MAPK-13 antibody, Mapk13 antibody, MGC99536 antibody, Mitogen activated protein kinase 13 antibody, Mitogen-activated protein kinase 13 antibody, Mitogen-activated protein kinase p38 delta antibody, MK13_HUMAN antibody, OTTHUMP00000016282 antibody, OTTHUMP00000016283 antibody, p38 delta antibody, P38delta antibody, PRKM13 antibody, SAPK 4 antibody, SAPK4 antibody, Stress activated protein kinase 4 antibody, Stress-activated protein kinase 4 antibody

UniProt: O15264

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung, Hepatitis C, BCR Signaling, S100 Proteine