TET2 Antikörper (AA 1833-2002)

Produktnummer ABIN7159637

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TET2 in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TET2 Antikörper (AA 1833-2002) (ABIN7159637)

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TET2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-TET2 Antikörper

Bindungsspezifität: AA 1833-2002

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Methylcytosine dioxygenase TET2 protein (1833-2002AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Andere Bezeichnung: TET2

Hintergrund:

Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Aliases: FLJ20032 antibody, KIAA1546 antibody, MDS antibody, Methylcytosine dioxygenase TET2 antibody, Nbla00191 antibody, Probable methylcytosine dioxygenase TET2 antibody, Protein Ayu17 449 antibody, Tet 2 antibody, Tet methylcytosine dioxygenase 2 antibody, Tet oncogene 2 antibody, Tet oncogene family member 2 antibody, TET2 antibody, TET2_HUMAN antibody

UniProt: Q6N021

Pathways: Warburg Effekt