LOXL2 Antikörper (AA 27-121) (Biotin)

Produktnummer ABIN7158838

Dieses Anti-LOXL2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LOXL2 in ELISA. Geeignet für Human.

Kurzübersicht für LOXL2 Antikörper (AA 27-121) (Biotin) (ABIN7158838)

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LOXL2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-LOXL2 Antikörper (Biotin)

Bindungsspezifität: AA 27-121

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Lysyl oxidase homolog 2 protein (27-121AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LOXL2

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Andere Bezeichnung: LOXL2

Hintergrund:

Background: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated \'Lys-4\' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Aliases: LOR 2 antibody, LOR2 antibody, LOX L2 antibody, LOXL 2 antibody, LOXL2 antibody, LOXL2_HUMAN antibody, Lysyl oxidase homolog 2 antibody, Lysyl oxidase like 2 antibody, Lysyl oxidase like protein 2 antibody, Lysyl oxidase related 2 antibody, Lysyl oxidase related protein 2 antibody, Lysyl oxidase related protein WS9 14 antibody, Lysyl oxidase-like protein 2 antibody, Lysyl oxidase-related protein 2 antibody, Lysyl oxidase-related protein WS9-14 antibody, WS9 14 antibody

UniProt: Q9Y4K0

Pathways: Chromatin Binding