KIDINS220 Antikörper (AA 1077-1370) (HRP)

Produktnummer ABIN7157553

Der Kaninchen Polyklonal Anti-KIDINS220-Antikörper wurde für ELISA validiert. Er ist geeignet, KIDINS220 in Proben von Human zu detektieren.

Kurzübersicht für KIDINS220 Antikörper (AA 1077-1370) (HRP) (ABIN7157553)

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIDINS220 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-KIDINS220 Antikörper (HRP)

Bindungsspezifität: AA 1077-1370

Verwendungszweck: KIDINS220 Antibody, HRP conjugated

Aufreinigung: Protein G purified

Reinheit: >95 %

Immunogen: Recombinant Human Kinase D-interacting substrate of 220 kDa protein (1077-1370AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KIDINS220

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Andere Bezeichnung: KIDINS220

Hintergrund:

Background: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Aliases: Ankyrin repeat-rich membrane-spanning protein antibody, arms antibody, KDIS_HUMAN antibody, kidins220 antibody, Kinase D interacting substance of 220 kDa antibody, Kinase D-interacting substrate of 220 kDa antibody, rgd 619949 antibody

UniProt: Q9ULH0