AIM2 Antikörper (AA 81-326) (FITC)

Produktnummer ABIN7156705

Dieses Anti-AIM2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von AIM2 in . Geeignet für Human.

Kurzübersicht für AIM2 Antikörper (AA 81-326) (FITC) (ABIN7156705)

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AIM2 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-AIM2 Antikörper (FITC)

Bindungsspezifität: AA 81-326

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Interferon-inducible protein AIM2 protein (81-326AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu AIM2

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Andere Bezeichnung: AIM2

Hintergrund:

Background: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Aliases: Absent in melanoma 2 antibody, AIM 2 antibody, Aim2 antibody, AIM2_HUMAN antibody, Interferon-inducible protein AIM2 antibody, OTTHUMP00000035296 antibody, PYHIN4 antibody

UniProt: O14862

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome