GANP Antikörper (AA 292-435) (Biotin)

Produktnummer ABIN7153844

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GANP in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für GANP Antikörper (AA 292-435) (Biotin) (ABIN7153844)

Target: GANP (MCM3AP) (Minichromosome Maintenance Complex Component 3 Associated Protein (MCM3AP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GANP Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-GANP Antikörper (Biotin)

Bindungsspezifität: AA 292-435

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Germinal-center associated nuclear protein (292-435AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu GANP

Target: GANP (MCM3AP) (Minichromosome Maintenance Complex Component 3 Associated Protein (MCM3AP))

Andere Bezeichnung: MCM3AP

Hintergrund:

Background: Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.

Aliases: 80 kDa MCM3 associated protein antibody, 80 kDa MCM3-associated protein antibody, FLJ44336 antibody, FLJ45306 antibody, Germinal center associated nuclear protein antibody, KIAA0572 antibody, MAP80 antibody, MCM3 import protein antibody, MCM3 minichromosome maintenance deficient 3 associated protein antibody, MCM3A antibody, MCM3A_HUMAN antibody, Mcm3ap antibody, Minichromosome maintenance complex component 3 associated protein antibody, Minichromosome maintenance deficient 3 associated protein antibody, Minichromosome maintenance protein 3 associated protein antibody, Protein GANP antibody, SAC3 antibody

UniProt: O60318

Pathways: Protein targeting to Nucleus