Cyclin D3 Antikörper (AA 1-292)

Produktnummer ABIN7153394

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Cyclin D3 in WB, ELISA, IHC, IP und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Cyclin D3 Antikörper (AA 1-292) (ABIN7153394)

Target: Cyclin D3 (CCND3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Produktdetails anti-Cyclin D3 Antikörper

Bindungsspezifität: AA 1-292

Verwendungszweck: CCND3 Antibody

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human G1/S-specific cyclin-D3 protein (1-292AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Cyclin D3

Target: Cyclin D3 (CCND3)

Andere Bezeichnung: CCND3

Hintergrund:

Background: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Aliases: CCND 3 antibody, Ccnd3 antibody, CCND3_HUMAN antibody, CyclinD3 antibody, D3 type cyclin antibody, G1 S specific cyclin D3 antibody, G1/S specific cyclin D3 antibody, G1/S-specific cyclin-D3 antibody

UniProt: P30281

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process