PERK Antikörper (AA 115-330)
Kurzübersicht für PERK Antikörper (AA 115-330) (ABIN7152141)
Target
Alle PERK (EIF2AK3) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 115-330
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Kreuzreaktivität
- Human
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Aufreinigung
- >95%, Protein G purified
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Immunogen
- Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 3 protein (115-330AA)
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Isotyp
- IgG
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Applikationshinweise
- Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
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Andere Bezeichnung
- EIF2AK3
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Hintergrund
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Background: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on \'Ser-52\' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Aliases: DKFZp781H1925 antibody, E2AK3_HUMAN antibody, EC 2.7.11.1 antibody, Eif2ak3 antibody, Eukaryotic translation initiation factor 2 alpha kinase 3 antibody, Eukaryotic translation initiation factor 2-alpha kinase 3 antibody, Heme regulated EIF2 alpha kinase antibody, HRI antibody, HsPEK antibody, Pancreatic eIF2 alpha kinase antibody, Pancreatic eIF2-alpha kinase antibody, PEK antibody, PRKR like endoplasmic reticulum kinase antibody, PRKR-like endoplasmic reticulum kinase antibody, WRS antibody
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UniProt
- Q9NZJ5
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Pathways
- Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response
Target
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