PERK Antikörper (AA 115-330)

Produktnummer ABIN7152141

Der Kaninchen Polyklonal Anti-PERK Antikörper wurde für ELISA, IHC und IF validiert. Er ist geeignet, PERK in Proben von Human zu detektieren.

Kurzübersicht für PERK Antikörper (AA 115-330) (ABIN7152141)

Target: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PERK Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-PERK Antikörper

Bindungsspezifität: AA 115-330

Verwendungszweck: EIF2AK3 Antibody

Aufreinigung: Protein G purified

Reinheit: >95 %

Immunogen: Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 3 protein (115-330AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PERK

Target: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Andere Bezeichnung: EIF2AK3

Hintergrund:

Background: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on \'Ser-52\' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

Aliases: DKFZp781H1925 antibody, E2AK3_HUMAN antibody, EC 2.7.11.1 antibody, Eif2ak3 antibody, Eukaryotic translation initiation factor 2 alpha kinase 3 antibody, Eukaryotic translation initiation factor 2-alpha kinase 3 antibody, Heme regulated EIF2 alpha kinase antibody, HRI antibody, HsPEK antibody, Pancreatic eIF2 alpha kinase antibody, Pancreatic eIF2-alpha kinase antibody, PEK antibody, PRKR like endoplasmic reticulum kinase antibody, PRKR-like endoplasmic reticulum kinase antibody, WRS antibody

UniProt: Q9NZJ5

Pathways: Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response