RBX1 Antikörper (AA 1-108)

Produktnummer ABIN7151115

Der Kaninchen Polyklonal Anti-RBX1-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, RBX1 in Proben von Human zu detektieren.

Kurzübersicht für RBX1 Antikörper (AA 1-108) (ABIN7151115)

Target: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RBX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-RBX1 Antikörper

Bindungsspezifität: AA 1-108

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RBX1 protein (1-108AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RBX1

Target: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Andere Bezeichnung: RBX1

Hintergrund:

Background: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.

Aliases: BA554C12.1 antibody, E3 ubiquitin-protein ligase RBX1 antibody, FLJ60363 antibody, MGC13357 antibody, MGC1481 antibody, OTTHUMP00000028983 antibody, Protein ZYP antibody, Rbx 1 antibody, Rbx1 antibody, RBX1_HUMAN antibody, Regulator of cullins 1 antibody, Ring box 1 antibody, Ring box 1 E3 ubiquitin protein ligase antibody, RING box protein 1 antibody, RING finger protein 75 antibody, RING finger protein antibody, RING-box protein 1 antibody, Ringbox protein 1 antibody, RNF 75 antibody, RNF75 antibody, ROC 1 antibody, ROC1 antibody, ZYP protein antibody

UniProt: P62877

Pathways: Zellzyklus, M Phase, SARS-CoV-2 Protein Interaktom