AMFR Antikörper (AA 485-643) (FITC)

Produktnummer ABIN7150980

Der Kaninchen Polyklonal Anti-AMFR-Antikörper wurde für validiert. Er ist geeignet, AMFR in Proben von Human zu detektieren.

Kurzübersicht für AMFR Antikörper (AA 485-643) (FITC) (ABIN7150980)

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AMFR Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-AMFR Antikörper (FITC)

Bindungsspezifität: AA 485-643

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase AMFR protein (485-643AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu AMFR

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Andere Bezeichnung: AMFR

Hintergrund:

Background: E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.

Aliases: AMF receptor antibody, AMF receptor isoform 1 antibody, AMF receptor isoform 2 antibody, AMFR antibody, AMFR2_HUMAN antibody, Autocrine motility factor receptor antibody, Autocrine motility factor receptor precursor, isoform 1 antibody, Autocrine motility factor receptor precursor, isoform 2 antibody, E3 ubiquitin-protein ligase AMFR antibody, gp78 antibody, isoform 2 antibody, RING finger protein 45 antibody, RNF 45 antibody, RNF45 antibody

UniProt: Q9UKV5

Pathways: ER-Nucleus Signaling