PIAS4 Antikörper (AA 66-241)

Produktnummer ABIN7150970

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PIAS4 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PIAS4 Antikörper (AA 66-241) (ABIN7150970)

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIAS4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-PIAS4 Antikörper

Bindungsspezifität: AA 66-241

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 SUMO-protein ligase PIAS4 protein (66-241AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIAS4

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Andere Bezeichnung: PIAS4

Hintergrund:

Background: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Aliases: E3 SUMO protein ligase PIAS4 antibody, E3 SUMO-protein ligase PIAS4 antibody, FLJ12419 antibody, MGC35296 antibody, PAIASgamma antibody, PIAS 4 antibody, PIAS gamma antibody, PIAS-gamma antibody, Pias4 antibody, PIAS4_HUMAN antibody, PIASG antibody, PIASgamma antibody, PIASy antibody, Protein inhibitor of activated STAT 4 antibody, Protein inhibitor of activated STAT protein 4 antibody, Protein inhibitor of activated STAT protein gamma antibody, Protein inhibitor of activated STAT protein PIASy antibody, Zinc finger MIZ type containing 6 antibody, ZMIZ 6 antibody, ZMIZ6 antibody

UniProt: Q8N2W9

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus