PIAS2 Antikörper (AA 1-572)

Produktnummer ABIN7150964

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PIAS2 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PIAS2 Antikörper (AA 1-572) (ABIN7150964)

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIAS2 Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-PIAS2 Antikörper

Bindungsspezifität: AA 1-572

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 SUMO-protein ligase PIAS2 protein (1-572AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIAS2

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Andere Bezeichnung: PIAS2

Hintergrund:

Background: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at\'Lys-65\' and \'Lys-160\'.

Aliases: Androgen receptor interacting protein 3 antibody, Androgen receptor-interacting protein 3 antibody, ARIP3 antibody, DAB2 interacting protein antibody, DAB2-interacting protein antibody, DIP antibody, E3 SUMO protein ligase PIAS2 antibody, E3 SUMO-protein ligase PIAS2 antibody, MIZ antibody, Miz1 antibody, Msx interacting zinc finger protein antibody, Msx-interacting zinc finger protein antibody, PIAS NY protein antibody, PIAS-NY protein antibody, PIAS2 antibody, PIAS2_HUMAN antibody, PIASX antibody, PIASX-ALPHA antibody, PIASX-BETA antibody, Protein inhibitor of activated STAT x antibody, Protein inhibitor of activated STAT, 2 antibody, Protein inhibitor of activated STAT2 antibody, SIZ2 antibody, Zinc finger, MIZ-type containing 4 antibody, ZMIZ4 antibody

UniProt: O75928

Pathways: JAK-STAT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling