Mre11 Antikörper (AA 1-205)

Produktnummer ABIN7150623

Der Kaninchen Polyklonal Anti-Mre11-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, Mre11 in Proben von Human zu detektieren.

Kurzübersicht für Mre11 Antikörper (AA 1-205) (ABIN7150623)

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Mre11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Mre11 Antikörper

Bindungsspezifität: AA 1-205

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Double-strand break repair protein MRE11 protein (1-205AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Andere Bezeichnung: MRE11

Hintergrund:

Background: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3\\\'-5\\\' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Aliases: AT like disease antibody, Ataxia telangiectasia disorder like antibody, ATLD antibody, DNA recombination and repair protein antibody, Double strand break repair protein MRE11A antibody, Double-strand break repair protein MRE11A antibody, endo/exonuclease Mre11 antibody, HNGS1 antibody, meiotic recombination (S. cerevisiae) 11 homolog A antibody, Meiotic recombination 11 homolog 1 antibody, meiotic recombination 11 homolog A (S. cerevisiae) antibody, Meiotic recombination 11 homolog A antibody, M mMRE11A antibody, Mre 11 antibody, MRE 11a antibody, MRE 11b antibody, MRE11 homolog 1 antibody, MRE11 homolog A antibody, MRE11 homolog double strand break repair nuclease antibody, MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody, MRE11 meiotic recombination 11 homolog A antibody, MRE11_HUMAN antibody, MRE11A antibody, MRE11b antibody, OTTHUMP00000236830 antibody, OTTHUMP00000236831 antibody, OTTHUMP00000236832 antibody, OTTHUMP00000236833 antibody

UniProt: P49959

Pathways: DNA Reparatur