CDK12 Antikörper (AA 1309-1490) (Biotin)

Produktnummer ABIN7148852

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CDK12 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CDK12 Antikörper (AA 1309-1490) (Biotin) (ABIN7148852)

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK12 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-CDK12 Antikörper (Biotin)

Bindungsspezifität: AA 1309-1490

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Cyclin-dependent kinase 12 protein (1309-1490AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CDK12

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Andere Bezeichnung: CDK12

Hintergrund:

Background: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates \'Ser-5\' in CTD repeats that are already phosphorylated at \'Ser-7\', but can also phosphorylate \'Ser-2\'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Aliases: arginine/serine-rich antibody, Cdc2 related kinase arginine/serine rich antibody, CDC2 related protein kinase 7 antibody, Cdc2-related kinase antibody, CDC2-related protein kinase 7 antibody, Cdk12 antibody, CDK12_HUMAN antibody, Cell division cycle 2 related protein kinase 7 antibody, Cell division cycle 2-related protein kinase 7 antibody, Cell division protein kinase 12 antibody, CRK7 antibody, CRKR antibody, CrkRS antibody, Cyclin-dependent kinase 12 antibody, EC 2.7.11.22 antibody, hCDK12 antibody, kiaa0904 antibody, Pksc antibody

UniProt: Q9NYV4