CDK12 Antikörper (C-Term)

Produktnummer ABIN6260606

Produktdetails anti-CDK12 Antikörper

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK12 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: CD2L7 Antibody detects endogenous levels of total CD2L7.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CD2L7, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CDK12

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Andere Bezeichnung: CDK12 (CRKRS Produkte)

Synonyme: AC017581 antikoerper, CG7597 antikoerper, Dmel\\CG7597 antikoerper, anon-WO0140519.165 antikoerper, cg7597 antikoerper, dCDK12 antikoerper, gi24668141 antikoerper, CRK7 antikoerper, CRKR antikoerper, CRKRS antikoerper, hCDK12 antikoerper, 1810022J16Rik antikoerper, AI646528 antikoerper, Crk7 antikoerper, Crkrs antikoerper, D11Ertd752e antikoerper, Pksc antikoerper, Cyclin-dependent kinase 12 antikoerper, cyclin dependent kinase 12 antikoerper, cyclin-dependent kinase 12 antikoerper, Cdk12 antikoerper, CDK12 antikoerper

Hintergrund:

Description: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Gene: CDK12

Molekulargewicht: 164 kDa

Gen-ID: 51755

UniProt: Q9NYV4