CDK12 Antikörper (AA 80-290)

Produktnummer ABIN7266230

Produktdetails anti-CDK12 Antikörper

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Bindungsspezifität: AA 80-290

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: CDK12 Rabbit pAb

Sequenz: SDTFSDDMAF KLDRRENDER RGSDRSDRLH KHRHHQHRRS RDLLKAKQTE KEKSQEVSSK SGSMKDRISG SSKRSNEETD DYGKAQVAKS SSKESRSSKL HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SSKQDDSPSG ASYGQDYDLS PSRSHTSSNY DSYKKSPGST SRRQSVSPPY KEPSAYQSST R

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-290 of human CDK12 (NP_057591.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CDK12

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Andere Bezeichnung: CDK12 (CRKRS Produkte)

Synonyme: AC017581 antikoerper, CG7597 antikoerper, Dmel\\CG7597 antikoerper, anon-WO0140519.165 antikoerper, cg7597 antikoerper, dCDK12 antikoerper, gi24668141 antikoerper, CRK7 antikoerper, CRKR antikoerper, CRKRS antikoerper, hCDK12 antikoerper, 1810022J16Rik antikoerper, AI646528 antikoerper, Crk7 antikoerper, Crkrs antikoerper, D11Ertd752e antikoerper, Pksc antikoerper, Cyclin-dependent kinase 12 antikoerper, cyclin dependent kinase 12 antikoerper, cyclin-dependent kinase 12 antikoerper, Cdk12 antikoerper, CDK12 antikoerper

Hintergrund: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.,CDK12,CRK7,CRKR,CRKRS,Cancer,Signal Transduction,Kinase,Tyrosine kinases,CDK12

Molekulargewicht: 141kDa/163kDa/164kDa

Gen-ID: 51755

UniProt: Q9NYV4