BBS5 Antikörper (AA 224-317) (HRP)

Produktnummer ABIN7145245

Dieses Anti-BBS5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BBS5 in ELISA. Geeignet für Human.

Kurzübersicht für BBS5 Antikörper (AA 224-317) (HRP) (ABIN7145245)

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BBS5 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-BBS5 Antikörper (HRP)

Bindungsspezifität: AA 224-317

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Bardet-Biedl syndrome 5 protein (224-317AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BBS5

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Andere Bezeichnung: BBS5

Hintergrund:

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

Aliases: Bardet Biedl syndrome 5 protein antibody, Bardet-Biedl syndrome 5 protein antibody, BBS5 antibody, BBS5_HUMAN antibody

UniProt: Q8N3I7

Pathways: Hedgehog Signalweg