Axin Antikörper (AA 418-707)

Produktnummer ABIN7145123

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Axin in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Axin Antikörper (AA 418-707) (ABIN7145123)

Target: Axin (AXIN1) (Axin 1 (AXIN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Axin Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Axin Antikörper

Bindungsspezifität: AA 418-707

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Axin-1 protein (418-707AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Axin

Target: Axin (AXIN1) (Axin 1 (AXIN1))

Andere Bezeichnung: AXIN1

Hintergrund:

Background: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects, down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

Aliases: AI316800 antibody, AXIN antibody, Axin 1 antibody, Axin-1 antibody, axin1 antibody, AXIN1_HUMAN antibody, Axis inhibition protein 1 antibody, Axis Inhibitor 1 antibody, Fu antibody, fused antibody, Fused, mouse, homolog of antibody, hAxin antibody, Kb antibody, Ki antibody, kinky antibody, knobbly antibody, MGC132911 antibody, MGC52315 antibody, PPP1R49 antibody, Protein Fused antibody, Protein phosphatase 1 regulatory subunit 49 antibody

UniProt: O15169

Pathways: WNT Signalweg, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling