Caveolin-1 Antikörper (AA 26-43) (Biotin)

Produktnummer ABIN7139772

Der Kaninchen Polyklonal Anti-Caveolin-1-Antikörper wurde für ELISA validiert. Er ist geeignet, Caveolin-1 in Proben von Human zu detektieren.

Kurzübersicht für Caveolin-1 Antikörper (AA 26-43) (Biotin) (ABIN7139772)

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caveolin-1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-Caveolin-1 Antikörper (Biotin)

Bindungsspezifität: AA 26-43

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Peptide sequence from Human Caveolin-1 protein (26-43AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Caveolin-1

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Andere Bezeichnung: CAV1

Hintergrund:

Background: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed: 25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed: 19262564).

Aliases: BSCL3 antibody, CAV antibody, CAV1 antibody, CAV1_HUMAN antibody, caveolae protein, 22 kD antibody, caveolin 1 alpha isoform antibody, caveolin 1 beta isoform antibody, Caveolin 1 caveolae protein 22 kDa antibody, Caveolin-1 antibody, Caveolin1 antibody, cell growth-inhibiting protein 32 antibody, CGL3 antibody, LCCNS antibody, MSTP085 antibody, OTTHUMP00000025031 antibody, PPH3 antibody, VIP 21 antibody, VIP21 antibody

UniProt: Q03135

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals