Caveolin-1 Antikörper (N-Term)

Produktnummer ABIN2854651

Produktdetails anti-Caveolin-1 Antikörper

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caveolin-1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit polyclonal antibody to Caveolin 1 (caveolin 1, caveolae protein, 22 kDa)
Caveolin 1 antibody [N1N3]

Aufreinigung: Purified by antigen-affinity chromatography.

Güteklasse: KO Validated

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Caveolin 1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: A431 , H1299 , HeLa , mouse lung , HeLa

Validation: KO/KD, Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-Caveolin-1 Antikörper (ABIN2854651)

Fang, Lin, Liang, Liang: "A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3-PBX1 and β-catenin-ABCG2 signaling." in: Journal of biomedical science, Vol. 27, Issue 1, pp. 42, (2020) (PubMed).

Details zu Caveolin-1

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Andere Bezeichnung: caveolin 1 (CAV1 Produkte)

Synonyme: fc07c04 antikoerper, wu:fc07c04 antikoerper, Cav-1 antikoerper, bscl3 antikoerper, cav1 antikoerper, cav1a antikoerper, cgl3 antikoerper, vip21 antikoerper, cav1b antikoerper, caveolin-1 antikoerper, cav antikoerper, mstp085 antikoerper, Caveolin-1 antikoerper, CAV1 antikoerper, cav-1 antikoerper, Cav antikoerper, caveolin 1 antikoerper, BSCL3 antikoerper, CGL3 antikoerper, MSTP085 antikoerper, PPH3 antikoerper, VIP21 antikoerper, caveolin 1 antikoerper, caveolin 1 L homeolog antikoerper, caveolin 1 S homeolog antikoerper, caveolin 1, caveolae protein antikoerper, caveolin 1, caveolae protein, 22kDa antikoerper, Caveolin antikoerper, cav1 antikoerper, cav1.L antikoerper, cav1.S antikoerper, CAV1 antikoerper, Cav1 antikoerper, cav-1 antikoerper

Hintergrund: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.

Cellular Localization: Golgi apparatus membrane , Cell membrane , Membrane , caveola

Molekulargewicht: 20 kDa

Gen-ID: 857

UniProt: Q03135

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals