CSF1R Antikörper (pTyr809)

Produktnummer ABIN7139076

Der Kaninchen Polyklonal Anti-CSF1R-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, CSF1R in Proben von Human zu detektieren.

Kurzübersicht für CSF1R Antikörper (pTyr809) (ABIN7139076)

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSF1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CSF1R Antikörper

Bindungsspezifität: pTyr809

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 809 (S-N-Y(p)-I-V) derived from Human M-CSF Receptor.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CSF1R

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Andere Bezeichnung: CSF1R

Hintergrund:

Background:

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development.

Sampaio NG, et al. (2011) J Cell Sci 124, 2021-31
21610095 Curated Info
Xiong Y, et al. (2011) J Biol Chem 286, 952-60
21041311 Curated Info
Yu W, et al. (2008) J Leukoc Biol 84, 852-63

Aliases: C FMS antibody, CD 115 antibody, CD115 antibody, CD115 antigen antibody, CFMS antibody, Colony stimulating factor 1 receptor antibody, Colony stimulating factor I receptor antibody, CSF 1 R antibody, CSF 1R antibody, CSF-1 receptor antibody, CSF-1-R antibody, CSF1 R antibody, CSF1R antibody, CSF1R_HUMAN antibody, CSFR antibody, EC 2.7.10.1 antibody, FIM 2 antibody, FIM2 antibody, FMS antibody, FMS proto oncogene antibody, FMS protooncogene antibody, HDLS antibody, M-CSF Receptor antibody, M-CSF-R antibody, Macrophage colony stimulating factor 1 receptor antibody, Macrophage colony stimulating factor I receptor antibody, Macrophage colony-stimulating factor 1 receptor antibody, McDonough feline sarcoma viral (v fms) oncogene homolog antibody, MCSFR antibody, Oncogen FMS antibody, Proto-oncogene c-Fms antibody, V-FMS McDonough feline sarcoma viral oncogen homolog, formerly antibody

UniProt: P07333

Pathways: RTK Signalweg, Inositol Metabolic Process, Cell-Cell Junction Organization