FGFR1 Antikörper (pTyr766)

Produktnummer ABIN7139064

Der Kaninchen Polyklonal Anti-FGFR1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, FGFR1 in Proben von Human zu detektieren.

Kurzübersicht für FGFR1 Antikörper (pTyr766) (ABIN7139064)

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-FGFR1 Antikörper

Bindungsspezifität: pTyr766

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 766 (Q-E-Y(p)-L-D) derived from FGFR1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FGFR1

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Andere Bezeichnung: FGFR1

Hintergrund:

Background:

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Cross MJ, et al. (2002) Mol Biol Cell 13, 2881-93. Foehr ED, Raffioni S, Murray-Rust J, Bradshaw RA (2001)J Biol Chem 276, 37529-36. Cross MJ, et al. (2000)J Cell Sci 113 ( Pt 4), 643-51 .

Aliases: Basic fibroblast growth factor receptor 1 antibody, bFGF-R-1 antibody, BFGFR antibody, CD331 antibody, CEK antibody, FGFBR antibody, FGFR 1 antibody, FGFR-1 antibody, FGFR1 antibody, FGFR1/PLAG1 fusion antibody, FGFR1_HUMAN antibody, fibroblast growth factor receptor 1 antibody, FLG antibody, FLT-2 antibody, FLT2 antibody, Fms-like gene antibody, Fms-like tyrosine kinase 2 antibody, fms-related tyrosine kinase 2 antibody, HBGFR antibody, heparin-binding growth factor receptor antibody, HH2 antibody, HRTFDS antibody, hydroxyaryl-protein kinase antibody, KAL2 antibody, N-SAM antibody, OGD antibody, Proto-oncogene c-Fgr antibody

UniProt: P11362

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteine