GAB2 Antikörper (pTyr643)

Produktnummer ABIN7139039

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GAB2 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für GAB2 Antikörper (pTyr643) (ABIN7139039)

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GAB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-GAB2 Antikörper

Bindungsspezifität: pTyr643

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 643(V-D-Y(p)-V-Q) derived from Human Gab2 .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu GAB2

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Andere Bezeichnung: GAB2

Hintergrund:

Background:

This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

Nishida K., Blood 93:1809-1816(1999).
Nagase T., DNA Res. 5:31-39(1998).
Salomon A.R., Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).

Aliases: GAB 2 antibody, Gab2 antibody, GAB2_HUMAN antibody, Grb 2 associated binder 2 antibody, GRB 2 associated binding protein 2 antibody, Grb2 associated binder 2 antibody, GRB2 associated binder 2 pp100 antibody, GRB2 associated binding protein 2 antibody, GRB2-associated binder 2 antibody, GRB2-associated-binding protein 2 antibody, Growth factor receptor bound protein 2 associated protein 2 antibody, Growth factor receptor bound protein 2-associated protein 2 antibody, KIAA0571 antibody, p97 antibody, PH domain containing adaptor molecule p97 antibody, pp100 antibody

UniProt: Q9UQC2

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, Warburg Effekt