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IGF1R Antikörper (pTyr1280)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IGF1R in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7138928

Kurzübersicht für IGF1R Antikörper (pTyr1280) (ABIN7138928)

Target

Alle IGF1R Antikörper anzeigen
IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reaktivität

  • 198
  • 111
  • 95
  • 16
  • 8
  • 8
  • 7
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 180
  • 38
  • 2
  • 2
  • 1
Kaninchen

Klonalität

  • 179
  • 42
  • 1
Polyklonal

Konjugat

  • 140
  • 9
  • 8
  • 8
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
Dieser IGF1R Antikörper ist unkonjugiert

Applikation

  • 141
  • 75
  • 71
  • 66
  • 32
  • 29
  • 28
  • 19
  • 13
  • 13
  • 5
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 23
    • 23
    • 19
    • 14
    • 12
    • 12
    • 12
    • 9
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1280

    Kreuzreaktivität

    Human

    Aufreinigung

    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

    Immunogen

    Peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y(p)-Y-S) derived from Human IGF-1R

    Isotyp

    IgG
  • Applikationshinweise

    WB:1:500-1:1000,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

    Andere Bezeichnung

    IGF1R

    Hintergrund

    Background:

    This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

    Adams, T.E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093
    Baserga, R. et al. (2000) Oncogene 19, 5574-5581
    Scheidegger, K.J. et al. (2000) J. Biol. Chem. 275, 38921-38928.
    O'Connor R, et al. Mol Cell Biol 1997 Jan, 17(1): 427-35

    Aliases: CD221 antibody, CD221 antigen antibody, IGF 1 receptor antibody, IGF 1R antibody, IGF I receptor antibody, IGF-I receptor antibody, Igf1r antibody, IGF1R_HUMAN antibody, IGFIR antibody, IGFIRC antibody, IGFR antibody, Insulin like growth factor 1 receptor antibody, Insulin like growth factor 1 receptor precursor antibody, Insulin-like growth factor 1 receptor beta chain antibody, Insulin-like growth factor I receptor antibody, JTK13 antibody, MGC142170 antibody, MGC142172 antibody, MGC18216 antibody, Soluble IGF1R variant 1 antibody, Soluble IGF1R variant 2 antibody

    UniProt

    P08069

    Pathways

    RTK Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagie
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