BRCA1 Antikörper (pSer1457)

Produktnummer ABIN7138430

Produktdetails anti-BRCA1 Antikörper

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Bindungsspezifität: pSer1457

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 1457 (L-T-S(p)-Q-K) derived from Human BRCA1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Andere Bezeichnung: BRCA1 (BRCA1 Produkte)

Hintergrund:

Background:

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

Miki Y., Science 266:66-71(1994).
Smith T.M., Genome Res. 6:1029-1049(1996).
Wilson C.A., Oncogene 14:1-16(1997).

Aliases: BRCA 1 antibody, BRCA1 antibody, BRCA1 DNA repair associated antibody, BRCA1/BRCA2 containing complex subunit 1 antibody, BRCA1/BRCA2-containing complex, subunit 1 antibody, BRCA1_HUMAN antibody, BRCAI antibody, BRCC 1 antibody, BRCC1 antibody, Breast and ovarian cancer susceptibility protein 1 antibody, Breast Cancer 1 antibody, Breast Cancer 1 Early Onset antibody, Breast cancer type 1 susceptibility protein antibody, BROVCA1 antibody, FANCS antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, Protein phosphatase 1 regulatory subunit 53 antibody, PSCP antibody, RING finger protein 53 antibody, RNF53 antibody

UniProt: P38398

Pathways: Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus