MAPT Antikörper (AA 725-729)

Produktnummer ABIN7138004

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAPT in WB und ELISA. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für MAPT Antikörper (AA 725-729) (ABIN7138004)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-MAPT Antikörper

Bindungsspezifität: AA 725-729

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around aa. 725-729(T-G-S-I-D) derived from Rat Tau

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: Mapt

Hintergrund:

Background: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Johnson , G.V. and Stoothoff , W.H. (2004) J. Cell Sci. 117, 5721-5729.
Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476.
Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.

Aliases: Mapt antibody, Mtapt antibody, Tau antibody, Microtubule-associated protein tau antibody, Neurofibrillary tangle protein antibody, Paired helical filament-tau antibody, PHF-tau antibody

UniProt: P19332

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size