CYFIP2 Antikörper

Produktnummer ABIN7129118

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CYFIP2 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CYFIP2 Antikörper (ABIN7129118)

Target: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYFIP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-CYFIP2 Antikörper

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of Human CYFIP2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CYFIP2

Target: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Andere Bezeichnung: CYFIP2

Hintergrund:

Background: CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

Aliases: CYFIP2 antibody, KIAA1168 antibody, PIR121Cytoplasmic FMR1-interacting protein 2 antibody, p53-inducible protein 121 antibody

UniProt: Q96F07

Pathways: RTK Signalweg, Apoptose, Positive Regulation of Endopeptidase Activity