Rekombinanter CDK4 Antikörper
Kurzübersicht für Rekombinanter CDK4 Antikörper (ABIN7127418)
Target
Alle CDK4 Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- CDK4 Recombinant Monoclonal Antibody
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Aufreinigung
- Affinity-chromatography
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Immunogen
- A synthesized peptide derived from human CDK4
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Isotyp
- IgG
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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 1-303) antibody
CDK4 Reaktivität: Human WB, IHC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305), (C-Term) antibodyCDK4 Reaktivität: Human WB, IF, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB03154 unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) antibodyKO Validated CDK4 Reaktivität: Human WB, IF, ICC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 6-295) antibodyCDK4 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (N-Term) antibodyCDK4 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 211-303) antibodyCDK4 Reaktivität: Human WB, ELISA, IF, RNAi Wirt: Maus Monoclonal 4F11 unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303), (C-Term) antibodyCDK4 Reaktivität: Ratte WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (N-Term) antibodyCDK4 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 201-303) antibodyCDK4 Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305) antibodyCDK4 Reaktivität: Human WB, ELISA, IHC, IF, FACS Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- WB:1:500-1:5000, IP:1:200-1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
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Andere Bezeichnung
- CDK4
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Hintergrund
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Background: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Aliases: Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3), CDK4
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UniProt
- P11802
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Pathways
- Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size
Target
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