TRIM24 Antikörper

Produktnummer ABIN7127116

Der Maus Monoklonal anti-TRIM24 Antikörper wird verwendet zum Nachweis von TRIM24 in Proben von Human. Er wurde validiert für IF und FACS.

Kurzübersicht für TRIM24 Antikörper (ABIN7127116)

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TRIM24 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-TRIM24 Antikörper

Spezifität: TIF1i±, also known as TRIM24, mediates transcriptional events by interactions with the AF2 region of several nuclear receptors, such as the estrogen, retinoic acid and vitamin D3 receptors. TIF1i± localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. TIF1i± is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains (RING, B-box type 1 and B-box type 2) and a coiled-coil region. The TIF1i± gene, which maps to human chromosome 7q33, encodes two alternatively spliced transcripts. However, the full length nature of one variant has not been determined. A TIF1i± homolog (designated bonus) has been identified in Drosophila and is associated with several genes that are implicated in the ecdysone pathway, a nuclear hormone receptor pathway required throughout Drosophila development, suggesting a conserved functional role for the protein throughout the course of evolution.

Kreuzreaktivität (Details): Human

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human TRIM24 protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or K562 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu TRIM24

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Andere Bezeichnung: TRIM24

Hintergrund: E3 ubiquitin protein ligase TRIM24, hTIF1, PTC6, RING finger protein 82, RNF82, TF1A, TIF1 alpha, Transcriptional intermediary factor 1 alpha, Tripartite motif-containing protein 24,TRIM24 / TIF1 alpha
Cellular localisation: Nucleus. Cytoplasm. Colocalizes with sites of active transcription.

Molekulargewicht: 117kDa

Gen-ID: 8805, 490287

UniProt: O15164