UXT Antikörper (AA 1-157)

Produktnummer ABIN7120577

Der Kaninchen Polyklonal Anti-UXT-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, UXT in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für UXT Antikörper (AA 1-157) (ABIN7120577)

Target: UXT (Ubiquitously-Expressed, Prefoldin-Like Chaperone (UXT))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UXT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-UXT Antikörper

Bindungsspezifität: AA 1-157

Verwendungszweck: UXT antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-157aa

Immunogen: ubiquitously-expressed transcript

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu UXT

Target: UXT (Ubiquitously-Expressed, Prefoldin-Like Chaperone (UXT))

Andere Bezeichnung: UXT

Hintergrund:

Synonyms: Protein UXT|Androgen receptor trapped clone 27 protein (ART-27)|Ubiquitously expressed transcript protein|UXT

Background: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription(AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation(PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling(PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC(PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function(PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM(PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

Molekulargewicht: 18 kDa

Gen-ID: 8409

UniProt: Q9UBK9

Pathways: Unfolded Protein Response