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TRIM24 Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TRIM24 in WB, ELISA, IHC und IP. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN7120279

Kurzübersicht für TRIM24 Antikörper (ABIN7120279)

Target

Alle TRIM24 Antikörper anzeigen
TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Reaktivität

  • 59
  • 24
  • 6
  • 6
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 2
  • 1
Human, Maus, Ratte

Wirt

  • 54
  • 6
  • 1
Kaninchen

Klonalität

  • 51
  • 10
Polyklonal

Konjugat

  • 40
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser TRIM24 Antikörper ist unkonjugiert

Applikation

  • 41
  • 21
  • 15
  • 9
  • 6
  • 5
  • 5
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    tripartite motif-containing 24

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:5000, IP: 1:200-1:2000, IHC: 1:50-1:200, IF: 1:50-1:500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    TRIM24 (Tripartite Motif Containing 24 (TRIM24))

    Andere Bezeichnung

    TRIM24

    Hintergrund

    Synonyms:HTIF1, PTC6, RING finger protein 82, RNF82, TF1A, TIF1, TIF1 alpha, TIF1A, TIF1ALPHA, TRIM24, tripartite motif containing 24 Background:Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4'(H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor(TR) and ESR1. Modulates transcription activation by retinoic acid(RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes(By similarity).

    Molekulargewicht

    117 kDa

    Gen-ID

    8805

    UniProt

    O15164
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