STIM1 Antikörper

Produktnummer ABIN7119554

Der Kaninchen Polyklonal Anti-STIM1-Antikörper wurde für WB, ELISA, IHC, IP, IF und FACS validiert. Er ist geeignet, STIM1 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für STIM1 Antikörper (ABIN7119554)

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STIM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-STIM1 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: stromal interaction molecule 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu STIM1

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Andere Bezeichnung: STIM1

Hintergrund: Synonyms:D11S4896E, GOK, STIM1, stromal interaction molecule 1 Background:STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER-plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. This antibody is rabbit polyclonal antibody raised against the N-terminal of human STIM1.

Molekulargewicht: 80kd

Gen-ID: 6786

UniProt: Q13586

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling