STIM1 Antikörper
Kurzübersicht für STIM1 Antikörper (ABIN7119554)
Target
Alle STIM1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- STIM1 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- stromal interaction molecule 1
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:1000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- STIM1 (Stromal Interaction Molecule 1 (STIM1))
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Andere Bezeichnung
- STIM1
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Hintergrund
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Synonyms: Stromal interaction molecule 1|STIM1|GOK
Background: STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER-plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. This antibody is rabbit polyclonal antibody raised against the N-terminal of human STIM1.
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Molekulargewicht
- 80 kDa
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Gen-ID
- 6786
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UniProt
- Q13586
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Pathways
- T-Zell Rezeptor Signalweg, BCR Signaling
Target
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