PSME4 Antikörper

Produktnummer ABIN7117899

Dieses Anti-PSME4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PSME4 in WB, ELISA, IHC, IP und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PSME4 Antikörper (ABIN7117899)

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSME4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Produktdetails anti-PSME4 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: proteasome(prosome, macropain) activator subunit 4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:500-1:1000 , IHC: 1:50-1:500, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu PSME4

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Andere Bezeichnung: PSME4

Hintergrund: Synonyms:KIAA0077 Background:Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP-and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like(BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Molekulargewicht: 140 kDa

Gen-ID: 23198

UniProt: Q14997

Pathways: DNA Replication, Synthesis of DNA