PARD3 Antikörper (AA 180-442)

Produktnummer ABIN7117224

Dieses Anti-PARD3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PARD3 in WB, ELISA, IHC, FACS und IP. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PARD3 Antikörper (AA 180-442) (ABIN7117224)

Target: PARD3 (Par-3 Partitioning Defective 3 Homolog (PARD3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)

Produktdetails anti-PARD3 Antikörper

Bindungsspezifität: AA 180-442

Verwendungszweck: PARD3 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 180-442aa

Immunogen: Partitioning defective 3 homolog

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:50-1:200, IF: 1:50-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu PARD3

Target: PARD3 (Par-3 Partitioning Defective 3 Homolog (PARD3))

Andere Bezeichnung: PARD3

Hintergrund:

Synonyms: Partitioning defective 3 homolog (PAR-3, PARD-3)|Atypical PKC isotype-specific-interacting protein (ASIP)|CTCL tumor antigen se2-5|PAR3-alpha|PARD3|PAR3|PAR3A

Background: Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination(By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.PARD3 has three splice isoforms at 100 kDa, 150 kDa, and 180 kDa. This polyclonal antibody raised against C-terminal 281 amino acids of human PARD3 recognizes these three isoforms.

Molekulargewicht: 100 kDa, 150 kDa, and 180 kDa

Gen-ID: 56288

UniProt: Q8TEW0

Pathways: Cell-Cell Junction Organization