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KISS1 Antikörper

Dieses Anti-KISS1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KISS1 in WB, IHC, ELISA und IF. Geeignet für Human und Maus.
Produktnummer ABIN7115721

Kurzübersicht für KISS1 Antikörper (ABIN7115721)

Target

Alle KISS1 Antikörper anzeigen
KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Reaktivität

  • 52
  • 17
  • 5
Human, Maus

Wirt

  • 52
  • 7
Kaninchen

Klonalität

  • 53
  • 6
Polyklonal

Konjugat

  • 40
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser KISS1 Antikörper ist unkonjugiert

Applikation

  • 30
  • 21
  • 14
  • 10
  • 10
  • 4
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    KiSS-1 metastasis-suppressor

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

    Andere Bezeichnung

    KISS1

    Hintergrund

    Synonyms:KiSS 1, KiSS 1 metastasis suppressor, KISS1, Kisspeptin 1, Metastasis suppressor KiSS 1, metastin Background:Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

    Molekulargewicht

    16-20 kDa

    Gen-ID

    3814

    UniProt

    Q15726

    Pathways

    Positive Regulation of Peptide Hormone Secretion
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