KIF7 Antikörper (AA 662-782)

Produktnummer ABIN7115710

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KIF7 in WB, ELISA und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für KIF7 Antikörper (AA 662-782) (ABIN7115710)

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIF7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Produktdetails anti-KIF7 Antikörper

Bindungsspezifität: AA 662-782

Verwendungszweck: KIF7 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 662-782aa

Immunogen: kinesin family member 7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu KIF7

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Andere Bezeichnung: KIF7

Hintergrund:

Synonyms: Kinesin-like protein KIF7|KIF7

Background: Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog(Shh) and Indian hedgehog(Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and-independent mechanisms(PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes(By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation(By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development(By similarity).

Molekulargewicht: 150 kDa

Gen-ID: 374654

UniProt: Q2M1P5

Pathways: Hedgehog Signalweg