KIDINS220 Antikörper

Produktnummer ABIN7115686

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KIDINS220 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für KIDINS220 Antikörper (ABIN7115686)

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIDINS220 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-KIDINS220 Antikörper

Verwendungszweck: KIDINS220 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: kinase D-interacting substrate, 220kDa

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu KIDINS220

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Andere Bezeichnung: KIDINS220

Hintergrund:

Synonyms: Kinase D-interacting substrate of 220 kDa|Ankyrin repeat-rich membrane-spanning protein|KIDINS220|ARMS|KIAA1250

Background: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor(NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration(By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Molekulargewicht: 186-197 kDa

Gen-ID: 57498

UniProt: Q9ULH0