VEGFA Antikörper (AA 141-180)

Produktnummer ABIN707186

Der Kaninchen Polyklonal Anti-VEGFA-Antikörper wurde für WB, ELISA, IHC (p), IF (cc), IF (p) und IHC (fro) validiert. Er ist geeignet, VEGFA in Proben von Human, Ratte, Maus und Huhn zu detektieren. Es sind 6+ Publikationen verfügbar.

Kurzübersicht für VEGFA Antikörper (AA 141-180) (ABIN707186)

Target: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Reaktivität: Human, Ratte, Maus, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VEGFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-VEGFA Antikörper

Bindungsspezifität: AA 141-180

Kreuzreaktivität: Huhn, Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human VEGF-A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-VEGFA Antikörper (ABIN707186)

Fetoni, Eramo, Paciello, Rolesi, Samengo, Paludetti, Troiani, Pani: "The redox protein p66(shc) mediates cochlear vascular dysfunction and transient noise-induced hearing loss." in: Scientific reports, Vol. 6, pp. 25450, (2016) (PubMed).

Shi, Ko, Ko, Kim, Ko: "Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling." in: Biochimica et biophysica acta, Vol. 1853, Issue 5, pp. 1154-64, (2015) (PubMed).

Wang, Liao, Wang, Deng, Yu: "Transplantation of bone marrow stromal cells overexpressing human vascular endothelial growth factor 165 enhances tissue repair in a rat model of radiation-induced injury." in: Chinese medical journal, Vol. 127, Issue 6, pp. 1093-9, (2014) (PubMed).

Fetoni, Lattanzi, Eramo, Barba, Paciello, Moriconi, Rolesi, Michetti, Troiani, Paludetti: "Grafting and early expression of growth factors from adipose-derived stem cells transplanted into the cochlea, in a Guinea pig model of acoustic trauma." in: Frontiers in cellular neuroscience, Vol. 8, pp. 334, (2014) (PubMed).

Tian, Yang, Xiao, Huang, He, Ma, Xia, Shi: "Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model." in: The Journal of biological chemistry, Vol. 288, Issue 22, pp. 15988-6003, (2013) (PubMed).

Details zu VEGFA

Target: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Andere Bezeichnung: VEGF-A

Hintergrund:

Synonyms: VPF, VEGF, MVCD1, Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VEGFA

Background: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

Gen-ID: 7422

UniProt: P15692

Pathways: RTK Signalweg, Glycosaminoglycan Metabolic Process, Regulation of Cell Size, Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling